Flower-like 3D SnS decorated on nickel metal-organic framework for electrochemical detection of dimetridazole in food samples.

Dimetridazole (DMZ) is a broad-spectrum antibiotic effective against bacterial and protozoan infections in humans and poultry farms. However, excessive DMZ intake leads to harmful effects. Thus, minimizing its environmental presence is crucial for sustaining daily life. This study presents an innovative approach to construct flower-like SnS particle decorations on a nickel metal-organic framework (Ni-MOF@SnS) as an electrocatalyst for DMZ detection. The Ni-MOF@SnS/GCE sensor exhibits exceptional electrocatalytic behavior, including a significantly reduced detection limit of 1.6 nM, extensive linear ranges from 0.01 µM to 60 µM and from 60 µM to 231 µM at lower and higher DMZ concentrations, respectively. It also shows enhanced sensitivity (0.139 µA µM-1 cm-2) and remarkable selectivity for DMZ detection using differential-pulse voltammetry (DPV). Furthermore, the proposed sensor demonstrates good recovery results with actual food samples.

Facile synthesis of multifunctional zinc vanadate/polyaniline composite for photocatalytic degradation and supercapacitor applications.

Multifunctional Zn3V2O8/Polyaniline (ZnV/PANI) composite was prepared by in-situ oxidative polymerization method. The formation of ZnV and ZnV/PANI composite was proved by various characterization tools including such as FTIR, XRD, SEM, BET, VSM, TEM and XPS analysis. The average crystalline size calculated using Scherrer equation of ZnV and ZnV/PANI were found to be 45 nm and 92 nm respectively. From the Tauc plots the bandgap values (Eg) were found to be 2.4 eV and 2.0 eV for ZnV and ZnV/PANI respectively. The FE-SEM images clearly show the flakes incorporated cluster-like morphology. The BET surface area of ZnV and ZnV/PANI was found to be 22 m2 g-1 and 40 m2 g-1. The XPS results also confirm the successful formation of ZnV/PANI composite. The as-prepared samples were utilized as photocatalyst and electrode materials for energy applications. The ZnV/PANI composite showed an outstanding photocatalytic activity (94%) in the degradation of aqueous RhB dye under visible light irradiation. The optimum catalyst dosage for the degradation of 50 mL of 1 × 10-5 M RhB dye aqueous solution was 50 mg. The Langmuir-Hinselwood (L-H) kinetic model proves that the photodegradation mechanism follows pseudo-first order kinetics. Further, the supercapacitive behavior of the ZnV/PANI composite was tested using cyclic voltammetry (CV), galvanostatic charge-discharge (GCD) techniques in 1 M KOH electrolyte at the potential window of 0-0.55 V. ZnV/PANI electrode displayed a specific capacitance (Csp) of 664 F g-1 at 1 A/g. The satisfactory performance of ZnV/PANI composite is mainly ascribed to the synergistic effect of ZnV-PANI matrixes with the occurrence of multiple electroactive sites in the composite. The cycling stability test proved that ZnV/PANI electrode material retained 92% of its initial capacitance even after 6000 GCD cycles at 2 A/g. The finding of this study will help to determine the most efficient and cost-effective method for the removal of dyes from textile industry wastewater and also as an effective material for supercapacitor applications.

New insight of red seaweed derived Callophycin A as an alternative strategy to treat drug resistance vaginal candidiasis.

Marine natural products are recognised as one among the major contributors of several important biological functions. The arguments has made to utilization of natural products against different kinds of infectious diseases. In the present study, Callophycin A was successfully prepared and its anti-candidal activity was evaluated through in-vitro and in-vivo methods. The in-vitro results revealed that, Callophycin A significantly inhibits the azole resistant and sensitive C. albicans. Further, in-vivo animal experiments have shown the effective reduction in CFU of C. albicans from its beginning day of the treatment as compared to the disease control group. At the end of Callophycin A administration, there was a decrease in inflammatory response and immune molecules such as IL-6, IL-12, IL-17, IL-22, TNF-α, macrophages, CD4 and CD8 cells were observed. Whereas the animals in the disease control group expressed all the parameters with the elevated level as compared to the control group. There are no hematological abnormalities such as neutropenia, lymphocytosis and eosinophilia was observed in any animal groups except the disease control group. Finally, the evidence based prediction of anti-candidal efficacious of Callophycin A was demonstrated.